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When constructing these lineages, we only used differentiating basal, secretory, and ciliating/ciliated populations, where lineages were constrained to begin with the differentiating basal population and to end with either the mature secretory (secretory cell 2) or mature ciliated populations

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Further, the placebo group had a 10% smoking abstinence rate, which is lower than the average placebo rate we typically observed in earlier years of our program, but may reflect that current smokers are more difficult to treat [8, 16]

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